There is some evidence that individual characteristics like Type A and high reactivity can be risk factors of alleviated stress. The aim of the first, longitudinal study was to predict perceived job stressors in a sample of 126 managers depending on Type A and reactivity level. The results showed that reactivity, not Type A, was a direct, positive predictor of perceived job stressors. The interaction of Type A and reactivity was marginally significant in predicting occupational stressors. High reactive Type A workers perceived higher level of job stressors than low reactive Type As. In the second, experimental study the changes in perceptions of job stressors due to mindfulness-based cognitive stress management intervention were examined in 150 managers matched by reactivity level (high or low) and Type A/B. In the experimental group, which participated in the intervention, the perceived level of job stressors decreased significantly in comparison with the control group, which did not take part in the intervention. Additionally, it was showed that the greatest decrease occurred in the group of high reactive workers who participated in the intervention. The role of Type A, reactivity and their interaction in predicting and managing occupational stress is discussed.