PL EN


2009 | 20 | 17-30
Article title

GENOME WIDE ASSOCIATION STUDIES IN SCHIZOPHRENIA AND BIPOLAR DISORDER (Badania asocjacyjne calego genomu w schizofrenii i zaburzeniach afektywnych dwubiegunowych)

Title variants
Languages of publication
PL
Abstracts
EN
Schizophrenia and bipolar disorder are heritable common disorders. Within the last years a number of genome wide association studies (GWAS) of schizophrenia and BP have been published. The study support strong evidence for association to specific risk loci, specifically for to zinc finger binding protein 804A (ZNF804A) locus for schizophrenia and for the calcium channel, voltage-dependent, L type, alpha 2C subunit (CACNA1C) and ankyrin 3 node of Ranvier (ANK3) loci in bipolar disorder. The ZNF804 and CACNA1C loci influence risk to both disorders. In schizophrenia a number of rare copy number variation have been detected (CNV), also CNV influence risk of other neurodevelopmental disorders such as autism and mental retardation. The results of existing studies point to some likely pathophysiological mechanisms but also challenge our current concept of classification of psychiatric disorders.
Year
Volume
20
Pages
17-30
Physical description
Document type
ARTICLE
Contributors
  • Joanna Hauser, Uniwersytet Medyczny w Poznaniu, Zaklad Genetyki w Psychiatrii, ul. Szpitalna 27-35, 60-572 Poznan, Poland
References
Document Type
Publication order reference
Identifiers
CEJSH db identifier
10PLAAAA074715
YADDA identifier
bwmeta1.element.17c886ba-0a0a-39f3-86fc-848cba4c1d68
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.