The paper presents current scientific literature review concerning effect of psychotropic medication on highly integrated functions of brain and mind on biological and psychological levels. The effects of medication is not mechanistic but is dependent on psychological and social aspects of situation of the individual person under treatment. After it's administration the dynamic interplay between different psychological and biological processes occur. The review of neurobiological aspects of placebo effects, action of antidepressants on emotional information processing and anxiolytics on fear processing is presented. The paper presents also the theory of psychosis as a state of aberrant salience and the action of antipsychotic drugs in the context of dampening of excessive salience. The results of this research and theories show how complex are mechanism of psychotropic medication influences on human mind.