Health resort Piešťany is an original and specific place. It has for a long time been a multicultural urban space, where the spa guests (bearers of their own cultures) meet the local inhabitants (bearers of the autochthonous culture). Together they create a society of the spa resort that, in spite of being in many respects indifferentiated or even contrasting, in general functions synchronously. The reason is the common adaptation strategy – the culture of the health resort. In the memory and identity of the town, the intense and dynamic sociocultural changes remain present in various ways (from artefacts through socionormatives to ideas). Among the most important belong the cultural landscape, architecture and urbanism, specific stratification of local inhabitants, as well as of the clients. Through historiographical and ethnocultural description it is possible to trace the changes and to identify factors that caused them.