Background: The examination of the physicians' special stress burden and burn-out syndrome are the aim of our pilot-study. Previous studies have shown that physicians have an increased risk of somatic and mental health problems such as depression, suicide and substance abuse. Work-related stress symptoms and burnout seemed to be the most important factors. Method: The 57 participants of the qualitative survey were physicians chosen randomly from the public health system in Hungary. Their special stress burden and burn-out syndrome have been examined through structured in-dephts interviews. Results: Three factors of the work related stress were investigated and proved to be interconnected: the special aspects of medical profession (on-call duties, high working tempo, long-working hours, frequency of stressful situations and emotionally provoking problems) work environment and control above the work. Female physicians (balancing their work and family responsibilities) and young doctors are especially at burnout and also at work-stress risk. Conclusions: Burnout correlates mostly to work-stress and role conflicts. It is affected by outer reasons, appreciation of stress and simultaneous compliance of roles beset with difficulties in particular. Further monitoring of work-stress and burnout causes could contribute to more efficient conflict treatment and health promotion methods in behalf of the Hungarian physicians.