This study examined the validity of the Wechsler Adult Intelligence Scale - Revised (WAIS-R) for the assessment of neurocognitive changes and their relationships with quality of life in HIV seropositive men. It was of interest to determine the sensitivity of additional performance parameters (the time of completion) for the identification of HIV-related cognitive deficit. Results indicated a progressive increase in the prevalence of HIV+ subjects with neuropsychological impairment. The most severe deficits in HIV+ groups were observed on Performance WAIS-R subtests and one Verbal subtest (Vocabulary). The scores on the Performance Intelligence Quotient were significantly correlated with several areas of daily function measured by the Sickness Impact Profile. The findings were comparable to the data demonstrated in previous investigations, some of which included extensive batteries of neuropsychological tests. Thus, the WAIS-R may be effective in some clinical or experimental settings, as a brief, yet relatively comprehensive evaluation of the cognitive deficits associated with HIV infection.