The study presents the creative personality profile from the point of view of five personality dimensions (neuroticism, extraversion, openness, agreeableness, conscientiousness) in relation to creative thinking of the adolescents, namely of the gender differences. For the creativity identification use was made of the Torrance Test of Creative Thinking. To measure the personality dimensions, the NEO Five-Factor Inventory (Costa, McCrae, 1989) was applied to a sample of 370 adolescents (196 boys and 174 girls, mean age 18 years). This research has yielded several remarkable results. We found the significant differences between the girls and boys in neuroticism and openness.