Qian Zhongshu was one of the greatest contemporary scholars, novelists and men of letters, and he also was one of the great literary comparativists of the world because of his burning wit and formidable erudition. Qian is distinguished among other writers and scholars for his broad understanding of both the Chinese classics and Western literary traditions. This essay discusses Qian Zhongshu’s role as a grand master who interconnects Chinese and Western cultures. The first part introduces Qian’s creative writing before the 1940’s. The second part presents Qian’s formidable interpretation of Chinese classical literary and artistic traditions in On the Arts of Poetry and Limited Views and the grand pattern of Qian’s works. The third part discusses the influence of Qian’s principle of “harmony without uniformity” in Sino-Western intercultural dialogue. All in all, Qian Zhongshu established the great example of comparative culture study of the East and the West.