The following article focuses on the issue of pharmaceutical crime. Procedures of law enforcement authorities are being reviewed before the commencement of criminal prosecution or in the so- called pre-trial procedures where information that suggests suspicion of any of the pharmaceutical crimes. In the introduction of the article, the authors briefly outline the meaning of terms such as pharmaceutical crime, detection, prevention and elimination of crime in order to gain a better understanding of the issue under consideration, as well as the basic aspects of law enforcement procedures in pre-trial proceedings. The article is further divided into five chapters dealing with the details of the process of detecting pharmaceutical crime, which includes the theoretical foundations of law enforcement practices in detecting pharmaceutical crime, detecting indicators suggesting the commission of this type of crime, including the process of obtaining them, places of potential the occurrence of these indicators and authorities that are able to detect these indicators. The next chapters analyse the specifics of the realization of the operative-search activity and the possibilities of using individual methods of operative-search activities in the process of operative elaboration of individual suspicions suggesting the committing of pharmaceutical criminality. Specifically, we are speaking about analysis of the possibilities of using individual supporting methods of operative-search activity, means of operative-search activity, means of information technology intelligence gathering and means of securing items important for criminal proceedings. In conclusion will be summarized the results of the researched issues achieved by using the relevant scientific methods.