In the article I compare the psycho-physical dualism of Nicolas Malebranche and Henri Bergson. The study of these two systems is important because Bergson is often critical of modern theories claiming a parallelism of soul and body. Malebranche bases his system on the category of space, while Bergson rejects the spatial view of reality and bases his conception on the notion of duration. On the one hand, Bergson criticizes the Cartesian dualistic conception. Yet, on the other hand, he builds his system in reference to modern solutions. The comparison of these two significantly different conceptions gives a more profound understanding of the problem of psycho-physical dualism. Furthermore, it makes possible a better appreciation of the innovative character of Bergson’s proposal. I consider the relation between mind and brain by means of an analysis of sensation because in both theories it is here that soul and body meet.