The purpose of this study is to investigate the relationship between innovation diffusion and human resource information system (HRIS). The theoretical framework of this study is based on the previous literature discussing innovation and HRIS. Innovation was treated as an independent variable, whereas HRIS was dealt with as a dependent variable. A survey questionnaire was used and sent to the human resource executives and the human resource professionals working at the pharmaceutical sector in Jordan to collect the data of this study with a response rate of 85%. It was found that there is a positive relationship between innovation diffusion and HRIS. More specifically, it was found that there is a relationship between relative advantage, compatibility, trialability and observability on the one hand and HRIS functions on the other. However, it was found that there is no relationship between complexity as a dimension of innovation diffusion and HRIS functions.