This article describes the main developments in trading activities in the Spiš region. This region was a major trading area, which boasted important international trading routes from prehistoric times. Settlements were built on and near these trading routes, later giving rise to the markets. The settlements engaged in international trade in the Spiš region as early as in the thirteenth century. Besides the chief trading centres of Kežmarok and Levoča, there were numerous medium-sized cities, which have also developed into important trading centres. For this reason, competition among these cities was characteristic of the economic development in this region.