Human trafficking is one of the most profitable spheres of national and transnational organized group activities and, according to specialists, it occupies the third place after drug and arms trafficking. The author provides an analysis of the main factors influencing the development of human trafficking as well as the way of fighting against that criminal activity during the financial crisis by the example of the Russian Federation, the USA and some other countries. These factors are divided into four groups: human trafficking supply, human trafficking demand, criminal activity environment, law enforcement activity. The factors are applied to both the countries of origin and the countries of destination. A few indexes are considered, such as unemployment, level of salary, minimum needs, level of remittances from legal and illegal migrants, national, international and private investment into the human trafficking fight, internet development, visa requirements, lax law enforcement. The analysis covers different types of human trafficking such as sex and labor trafficking, child labor and sex exploitation at the international and national levels. The author draws certain conclusions about a possible development of these types of human trafficking, including the internal trafficking, considering the economical and social changes caused by the world financial crisis.