Introduction: Circulatory system diseases have high medical and social significance, therefore, the study of the quality of life associated with health for cardiological patients is of great practical importance. A large number of methods for assessing the quality of life are known, but not all methods have a methodological justification in cardiology and practical approbation. The aim of the work was to assess the clinical value of the WHOQOL-100 questionnaire for a group of patients with cardiovascular diseases. Materials and methods: The work methodology is presented by the analysis of RISC, Springer Link, Oxford University Press, New England Medical Journal, British Medical Journal, Elsevier SCOPUS database, EBSCO platform, as a result, the WHOQOL100 method was justified for use. Results: It has been established that the psychological field (the ratio of positive and negative emotions) and the sphere of social relations with an emphasis on practical social support are components of the quality of life, which can be considered as key vectors of social rehabilitation and criteria for the social effectiveness of treating patients with cardiovascular diseases. Conclusion: The international questionnaire WHOQOL-100 is recommended for use for cardiological patients with the subsequent analysis of the whole profile of quality of life.