Medical causes are also concerned to be causes of divorce in Christian Byzantium. These diseases included leprosy, madness and impotence of male, and they are studied in the present short historical article. In the cause of divorce for Madness, whilst the wife has to wait five years to seek divorce, the husband has to wait only three years. In the cause of divorce for Impotence of the male, the wife should wait for three years in case of recovery. In the cause of Leprosy, it seems that the disease was a cause of divorce only if it concerned the wife. With these laws, therefore, the Byzantine leaders protected not only the health of people but also society’s health in general.