Clinical usefulness of MMP-2 and TIMP-2 concentrations in the preoperative serum of patients with colorectal cancer

• Authors: Pryczynicz, A , Gryko, M , Dymicka-Piekarska, V , Lewczuk, Ł , Wakulewska, A , Ozimkiewicz, M , Lebelt, A , Guzińska-Ustymowicz, K

Abstracts

EN

Purpose: To evaluate the clinical significance of MMP-2 and TIMP-2 concentrations in the sera of patients diagnosed with colorectal cancer. Methods: The study group comprised 48 patients with colorectal carcinoma and 24 healthy controls. The serum concentration of MMP-2 and TIMP-2 proteins was evaluated by the ELISA method. Results: The mean level of MMP-2 in the sera of patients with colorectal cancer was 39.4 ng/ml and was significantly lower compared with the control (p<0.001). A decrease in TIMP-2 protein in the sera of patients with colorectal cancer was also observed where its mean level was 132.3 ng/ml. The concentration of MMP-2 and TIMP-2 did not correlated with any clinicopathological parameters, except for the patients’ age. In addition, the concentration of MMP-2 in the sera of patients with CRC correlated negatively with the number of white blood cells in the blood and the prothrombin index. The concentration of TIMP-2 correlated positively with potassium and urea concentration in the blood. Conclusions: The results of our study indicate lack of clinical usefulness of determining the levels of MMP-2 and TIMP-2 in the sera of patients with colorectal cancer. However, these proteins play an important role in the carcinogenesis of colorectal cancer.

Keywords

EN

Colorectal cancer; matrix metalloproteinases; MMP-2; TIMP-2; serum marker

• Publisher: Uniwersytet Medyczny w Białymstoku
• Journal: Progress in Health Sciences
• Year: 2016
• Volume: 6(1)
• Pages: 32-39

Contributors

author

Pryczynicz, A

author

Gryko, M

author

Dymicka-Piekarska, V

author

Lewczuk, Ł

author

Wakulewska, A

author

Ozimkiewicz, M

author

Lebelt, A

author

Guzińska-Ustymowicz, K

Identifiers

DOI

10.5604/01.3001.0009.5107