The contemporary ideology and the practice of transhumanism are carrying a lot of improvements of the human life with themselves, both in the individual dimension, like social. It can, however, also become a cause of objectifying, incapacitating or even annihilating individual people or entire populations. The applying of GRIN technologies are threatening of manipulation on the level of mental and physical structure of the organism. In the face of progressing technological changes the permanent philosophical discussion about norms of bioethics and social ethics is necessary. In the article an applicability of hedonistic and personalistic philosophies is being discussed. There is pointing on personalism as the appropriate basis of ethics in the era transhumanism.