Granulocyte colony-stimulating factor potential use in the treatment of children with cerebral palsy

• Authors: Paszko-Patej, G , Sienkiewicz, D , Okurowska-Zawada, B , Kułak, W

Abstracts

EN

Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the blood. Recent studies demonstrated the presence of CSF-receptor (G-CSFR) system in the brain and spinal cord, and their roles in neuroprotection and neural tissue repair, as well as improvement in functional recovery. G-CSF exerts neuroprotective actions through the inhibition of apoptosis and inflammation, and the stimulation of neurogenesis. This review highlights recent studies on the potential use of G-CSF in cerebral palsy.

Keywords

EN

Granulocyte colony-stimulating factor; neuroprotection; studies; cerebral palsy

• Publisher: Uniwersytet Medyczny w Białymstoku
• Journal: Progress in Health Sciences
• Year: 2017
• Volume: 7(1)
• Pages: 187-192

Contributors

author

Paszko-Patej, G

author

Sienkiewicz, D

author

Okurowska-Zawada, B

author

Kułak, W

Identifiers

DOI

10.5604/01.3001.0010.1882