Significance of mucin expression in pancreatic intraepithelial neoplasia (PanIN) – precursor lesions of pancreatic ductal adenocarcinoma (PDAC)

• Authors: Zińczuk, J , Zaręba, K , Pryczynicz, A , Kuczyńska, P , Boroń, Z , Ustymowicz, W , Maciorkowska, M , Ćwiklińska-Dworakowska, M , Baszun, M , Jelski, S , Guzińska-Ustymowicz, K

Abstracts

EN

Purpose: To evaluate chosen mucins (mucin 1, 4, 5AC) expression in pancreatic intraepithelial neoplasia, which is a precursor lesion of pancreatic ductal adenocarcinoma. Materials and methods: The study group included 70 patients operated on due to inflammation, cysts and pancreatic ductal adenocarcinoma with pancreatic intraepithelial neoplasia revealed additionally. Mucin 1, 4 and 5AC expression was assessed by immunohistochemical method using polyclonal antibodies. Results: Statistical analysis proved a positive correlation between the expression of mucin 1, 4 and 5AC proteins and the presence and staging of pancreatic intraepithelial neoplasia (p<0.001). Statistically significant correlations were determined between mucin 1, 4 and 5AC and the location of PanIN lesion in the pancreas. Positive correlations were found between mucin 5AC expression and the type of a basic disease (p=0.014). Differences in the expression of MUC 1, 4 and 5AC proteins between healthy pancreatic ducts and various stages of pancreatic intraepithelial neoplasia were statistically significant (p<0.001). Conclusions: Overexpression of mucin 1, 4 and 5AC is related to the presence of pancreatic intraepithelial neoplasia. This suggests that overproduction of mucus is a phenomenon occurring early in the process of carcinogenesis in the pancreas and has its beginning in precancerous lesions of an early stage.

Keywords

EN

Mucin; immunohistochemistry; pancreatic intraepithelial neoplasia; PanIN

• Publisher: Uniwersytet Medyczny w Białymstoku
• Journal: Progress in Health Sciences
• Year: 2018
• Volume: 8(1)
• Pages: 63-73

Dates

published

2018-06-18

Contributors

author

Zińczuk, J

author

Zaręba, K

author

Pryczynicz, A

author

Kuczyńska, P

author

Boroń, Z

author

Ustymowicz, W

author

Maciorkowska, M

author

Ćwiklińska-Dworakowska, M

author

Baszun, M

author

Jelski, S

author

Guzińska-Ustymowicz, K

Identifiers

DOI

10.5604/01.3001.0012.1128