Detection of PRL-3 protein in the preoperative serum of patients with colorectal cancer

• Authors: Pryczynicz, A , Dymicka-Piekarska, V , Niewiarowska, K , Gryko, M , Niksa, M , Hawryluk, M , Kemona, A , Famulski, W

Abstracts

EN

Purpose: The aim of study was to detect PRL-3 protein in sera of patients with colorectal cancer. Methods: The study group consisted of 22 patients with colorectal carcinoma and 10 healthy controls. The serum concentration of PRL-3 protein was evaluated by the ELISA method. Results: In the study group with colorectal cancer, the level of PRL-3 protein in preoperative sera was negative (<0.115ng/ml) in 7 cases while the mean value of PRL-3 concentration was 0.616ng/ml (range 0.206-2.072ng/ml) in 15 patients. No statistically significant differences between the study group and healthy controls were observed. Our data showed that increase in level of PRL-3 protein in sera of patients with colorectal cancer is associated with greater tumor size (p<0.05). Conclusions: PRL-3 protein was found to be present in sera of patients with colorectal cancer. However, our study indicates lack of clinical usefulness of determining the levels of PRL-3 in the sera of patients with colorectal cancer.

Keywords

EN

colorectal cancer; PRL-3; serum.

• Publisher: Uniwersytet Medyczny w Białymstoku
• Journal: Progress in Health Sciences
• Year: 2013
• Volume: 3
• Issue: 1
• Pages: 49-53

Contributors

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Pryczynicz, A

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Dymicka-Piekarska, V

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Niewiarowska, K

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Gryko, M

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Niksa, M

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Hawryluk, M

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Kemona, A

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Famulski, W