The growth differentiation factor-15 (GDF-15) can be useful in the detection of distant metastases in sera of colorectal cancer patients

• Authors: Jakubowska, K , Pryczynicz, A , Dymicka-Piekarska, V , Cepowicz, D , Jagodzińska, D , Lewczuk, Ł , Lebelt, A , Ozimkiewicz, M , Kiszło, P , Guzińska-Ustymowicz, K

Abstracts

EN

Purpose: Growth differentiation factor-15 (GDF- 15) protein belongs to a transforming growth factor-β family which determines the growth and differentiation of cells. In cancers, GDF-15 influences on the proliferation, differentiation, viability, migration and invasiveness of cancer cells. The aim of our study was to evaluate the expression of GDF-15 in the tissue and its levels in sera of patients with colorectal cancer. Materials and methods: The level of GDF-15 in the sera of 55 patients diagnosed with colorectal cancer was determined using the ELISA method whereas expression of this protein was performed by immunohistochemical method. Results: The mean value of GDF-15 levels in the sera of patients with colorectal cancer was significantly higher than in healthy control group (p<0.001). The expression of GDF-15 in the tissue was weak, moderate and strong in 23.6%, 15.7% and 60.7% cases, respectively. Statistical analysis showed that the expression of GDF-15 correlated with patients’ age (p<0.005) and non-mucinous type of cancer (p<0.001). The high GDF-15 levels in the serum was associated with tumor size (p<0.01) and distant metastases (p<0.05). Conclusions: According to our results, we postulate that the level of GDF-15 in serum can be use to assess the metastatic behavior of colorectal cancer

Keywords

EN

Colorectal cancer; Growth differentiation factor-15; macrophage inhibitory cytokine-1; serum.

• Publisher: Uniwersytet Medyczny w Białymstoku
• Journal: Progress in Health Sciences
• Year: 2016
• Volume: 6(1)
• Pages: 40-48

Contributors

author

Jakubowska, K

author

Pryczynicz, A

author

Dymicka-Piekarska, V

author

Cepowicz, D

author

Jagodzińska, D

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Lewczuk, Ł

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Lebelt, A

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Ozimkiewicz, M

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Kiszło, P

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Guzińska-Ustymowicz, K

Identifiers

DOI

10.5604/01.3001.0009.5108