Spatial component of number representation has been broadly investigated during the past 20 years. Numerous studies in cognitive psychology and neuroscience indicate that number representations are automatically mapped in space. The aim of this paper is to discuss potential applications of spatial numerical associations in the domain of education. Theoretically, investigating spatial numerical associations may be useful for: (a) diagnostics of Math deficits, (b) assessment in Math education and (c) developing trainings and tools aimed at improving Math performance. Keeping recent results in mind, it seems that diagnostic power of spatial numerical associations is limited; nevertheless, possibilities of developing trainings of spatial mapping of numbers may be a fruitful area of application.