It is the aim of the article to depict the design and implementation of organizational innovation: Model SPIN. Model was tested at universities in Małopolska voivodship. It is based on the establishment and development of Knowledge Centers dedicated to the specific fields of technology (biotechnology, smart grids, green building, translational medicine). The implementation is discussed through the description of the risks associated with it. The article is concluded by the general reflections about the cooperation of public administration, universities and enterprises.