PL EN


2017 | 2 | 173-176
Article title

The significance of anti-DFS70 antibodies in the diagnosis of autoimmune disorders

Content
Title variants
Languages of publication
EN
Abstracts
Contributors
References
  • Tan EM. Autoantibodies and autoimmunity: a three-decade perspective. A tribute to Henry G. Kunkel. Ann NY Acad Sci 1997; 815:1–14.
  • Seelig CA , Bauer O, Seelig HP. Autoantibodies against DFS70/LED GF exclusion markers for Systemic Autoimmune Rheumatic Diseases (SARD ). Clin Lab 2016; 62(4): 499–517.
  • Bentow C, Rosenblum R, Correia P, et al. Development and multi-center evaluation of a novel immunoadsorption method for anti-DFS70 antibodies. Lupus 2016; 25(8): 897–904.
  • Ochs RL , Muro Y, Si Y, et al. Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions.J Allergy Clin Immunol 2000; 105(6 Pt 1): 1211–1220.
  • Daniels T, Zhang J, Gutierrez I, et al. Antinuclear autoantibodies in prostate cancer: immunity to LED GF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis. Prostate 2005; 62(1): 14–26.
  • Maertens G, Cherepanov P, Pluymers W, et al. LED GF/p75 is essential for nuclear and chromosomal argeting of HIV-1 integrase in human cells. J Biol Chem 2003; 278(35): 33528–33539.
  • Gundín S, Irure-Ventura J, Asensio E, et al. Measurement of anti-DFS70 antibodies in patients with ANA-associated autoimmune rheumatic diseases suspicion is cost-effective. Auto Immun Highlights 2016; 7(1): 10, doi: 10.1007/s13317-016-0082-1.
  • Singh DP, Ohguro N, Chylack LT Jr, et al. Lens epithelium-derived growth factor: increased resistance to thermal and oxidative stresses.Invest Ophthalmol Vis Sci 1999; 40(7): 1444–1445.
  • Singh DP, Kimura A, Chylack LT Jr, et al. Lens epithelium-derived growth factor (LED GF/p75) and p52 are derived from a single gene by alternative splicing. Gene 2000; 242(1–2): 265–273.
  • Ogawa Y, Sugiura K, Watanabe A, et al. Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal alpha-helical domain. J Autoimmun 2004; 23(3): 221–231.
  • Brown-Bryan TA , Leoh LS , Ganapathy V, et al. Alternative splicing and caspase-mediated cleavage generate antagonisticvariants of the stress oncoprotein LED GF/p75. Mol Cancer Res 2008; 6(8): 1293–1307.
  • Shinohara T, Singh DP, Fatma N. LED GF, a survival factor, activates stress-related genes. Prog Retin Eye Res 2002; 21(3): 341–358.
  • Sharma P, Singh DP, Fatma LT , et al. Activation of LED GF gene by thermal- and oxidative-stresses. Biochem Biophys Res Commun 2000;276(3): 1320–1324.
  • Basu A, Drame A, Muñoz R, et al. Pathway specific geneexpression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LED GF/p75 in PCa cells. Prostate 2012; 72(6): 597–611.
  • Llano M, Saenz DT , Meehan A, et al. An essential role for LED
  • Vandekerckhove L, Christ F, Van Maele B, et al. Transient and stable knockdown of the integrase cofactor LED GF/p75 reveals its role in the replication cycle of human immunodeficiency virus. J Virol 2006; 80(4): 1886–1896.
  • Ochs RL , Mahler M, Basu A, et al. The significance of autoantibodies to DFS70/LED GFp75 in health and disease: integrating basic science with clinical understanding. Clin Exp Med 2016; 16(3): 273–293.
  • Daniels T, Zhang J, Gutierrez I, et al. Antinuclear autoantibodies in PCa: immunity to LED GF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis. Prostate 2005; 62(1): 14–26.
  • O’Rourke DJ, DiJohnson DA , Caiazzo RJ Jr, et al. Autoantibody signatures as biomarkers to distinguish PCa from benign prostatic hyperplasiain patients with increased serum prostate specific antigen. Clin Chim Acta 2012; 413(5–6): 561–567.
  • Conrad K, Röber N, Andrade LE , et al. The clinical relevance of anti-DFS70 autoantibodies. Clin Rev Allergy Immunol 2016; 52(2):202–216, doi: 10.1007/s12016-016-8564-5.
  • Watanabe A, Kodera M, Sugiura K, et al. Anti-DFS70 antibodies in 597 healthy hospital workers. Arthritis Rheum 2004; 50: 892–900.
  • Huang TS , Myklebust LM, Kjarland E, et al. LED GF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro. Mol Cancer 2007; 6: 31.
  • Grand FH, Koduru P, Cross NC, et al. NUP98-LED GF fusion and t(9;11) in transformed chronic myeloid leukemia. Leuk Res 2005; 29(12): 1469–1472.
  • Méreau H, De Rijck J, Čermáková K, et al. Impairing MLL -fusion gene-mediated transformation by dissecting criticalinteractions with the lens epithelium-derived growth factor (LED GF/p75). Leukemia 2013; 27(6): 1245–1253.
  • Mahler M, Parker T, Peebles CL , et al. Anti-DFS70/LED GF antibodies are more prevalent in healthy individuals compared to patients with systemic autoimmune rheumatic diseases. J Rheumatol 2012; 39(11): 2104–2110.
  • Muro Y, Sugiura K, Nakashima R, et al. Low prevalence of anti-DFS70/LED GF antibodies in patients with dermatomyositis and other systemic autoimmune rheumatic diseases. J Rheumatol 2013; 40(1): 92–93.
  • Marlet J, Ankri A, Charuel JL, et al. Thrombophilia associated with antiDFS70 autoantibodies. PLoS One 2015; 10(9): e0138671, doi:10.1371/journal.pone.0138671.
  • Mahler M, Meroni PL, Andrade LE , et al. Towards a better understanding of the clinical association of anti-DFS70 autoantibodies.Autoimmun Rev 2016; 15(2): 198–201, doi: 10.1016/j.autrev.2015.11.006. Review.
  • Pisetsky DS . Antinuclear antibodies in healthy people: the tip of autoimmunity’s iceberg? Arthritis Res Ther 2011; 13(2): 109.
  • Fritzler MJ. The antinuclear antibody test: last or lasting gasp? Arthritis Rheum 2011; 63(1): 19–22. GF/p75 in HIV integration. Science 2006; 314(5798): 461–464.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.desklight-353d7ebd-34c5-47f5-8e92-c2536809d9a8
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.