Compliance of forms and methods of work to the tasks set are established according to the pilot program areas that meet the objectives of organizational, psychological, pedagogical, scientific and methodological provision of the preventive activities at schools. Prevention efficiency according to the criterion of compliance of forms and methods of work to the tasks set requires a corresponding level of theoretical knowledge of practitioners involved into the preventive activities. The ability of practitioners to deal with information on child’s social and psychological indicators is taken into account. It is important to take account of the practical implementation of the theory, legislative and regulatory framework as well as technologies. Practitioners’ availability and use of diagnostic and preventive tools, possession of knowledge on age, gender, psychological and pedagogical peculiarities of girls and their behavior are indicative. The implementation of the pilot program «Diagnosis and Prevention of Schoolgirls’ Deviant Behavior» (Ternopil region, 2009–2010) demonstrated positive results of the work done. Within the regional program action, according to the schoolgirls’ social and educational passports, a diagnostic and preventive tools used, the complexity of preventive influence was found. The execution of the tasks required improving professional level of the subjects of prevention, the activity of which is one of the main factors influencing girls, mastery of forms and methods of socio-pedagogical work, as the actualization of prevention of deviant behavior in girls is accompanied by organizational, psychological and pedagogical, research and methodological provision of preventive process in secondary schools. It was found out that in the prevention of girls’ deviant behavior the functional capabilities of institutions, organizations, and services which are responsible for the prevention are not fully captured. The analysis of statistical data, concerning girls, living in different locations allows us to state, that there are no differences that characterize the dependence of deviant behavior displays on health, life and values from the type locality. This is confirmed by the analysis of the social and psychological indicators and displays of various types of schoolgirls’ deviant behavior according to criterion of residence.