Knowledge management is done using a number of methods which form the knowledge management system. Among these methods a special place is occupied by the informatics methods for supporting knowledge management. The modernization of the organization and forms of work takes place also at universities. The effectiveness of the implemented methods improves knowledge management and increases universities’ contribution to the process of creating knowledge based economy. In the paper the most popular IT methods in knowledge management used by university employees together with an assessment of their effectiveness were presented. Te author defined also the concept of knowledge management process and pointed to the goals of knowledge management at universities. Moreover, the paper provides recommendations for universities for the selection of IT methods in knowledge management.