Massive Open Online Courses (MOOCs) have brought innovation in terms of learning modes and new challenges at all levels of education, aiming to respond to the most pressing learning needs, generated by the new development policies and the rapid evolution of technology. This wave of change is affecting also entrepreneurial education. The goal of this study is to evaluate the opportunities and limitations of massive open online courses posed to higher education institutions. The study is based on desk research and analysis of existing MOOCs dedicated to entrepreneurship. The paper starts with introductory information about entrepreneurship and entrepreneurship education, as well as a short description of MOOC types. Next it presents an overview of existing top ranked online courses devoted to entrepreneurship education around the world. Finally, the paper identifies both opportunities and limitations of entrepreneurship MOOCs in regard to higher education institutions programs, as well as best practices identified as a result of the study.