The main goal of the article is to analyze the problems and needs of individuals and families living with HIV/AIDS, and to identify characteristics of effective social and psychological support for representatives of the target group. Basic methods are: analysis of research and practice working with PLHIV, theoretical data generalization, synthesis features to determine social and psychological support for individuals and families living with HIV/AIDS in Ukraine. In the article we reitemized the basic aspects that determine the vulnerability of individuals and families (acceptance of the diagnosis and adherence to treatment, stigma and discrimination, self-stigma, drug addiction, domestic violence and other difficult life circumstances); were singled out typical problems and difficulties of HIV-infected people, their basic needs. The main objective of social and psychological support for individuals and families affected by HIV/AIDS was defined as improving their quality of life, protection of rights and interests, and combating further spread of HIV. Basic measures, the implementation of which has proved their effectiveness, were detailed: counseling individuals and families living with HIV/AIDS on a wide range of health; assistance in making status and/or disclosure of a child or family status; home patronage, and if it’s necessary – medical support; protection of rights and representation; organization of self-help groups and so on. Some characteristics of social and psychological support for individuals and families living with HIV/AIDS were determined. Materials of the article can be useful for scientists and practitioners who work in the provision of PLHIV. Based on the analysis of the theory and practice of socio-psychological support for individuals and families living with HIV/AIDS, we can conclude that the activities are aimed both at expanding the resources of the client and his family, and in the whole community, where PLHIV lives, and are focused on overcoming obstacles on the formation of adherence to treatment, overcoming self-stigma, improving the quality of life with HIV infection; effective support which is possible only through an integrated approach to problem solving and meeting the client’s needs and involves social workers, psychologists, doctors, lawyers – that is implemented in multidisciplinary team of specialists; to achieve high efficiency of such work is to use the fullest possible range of measures of social and psychological support of PLHIV and to consider the features of implementation of such activities.