Aktywność metaloproteinaz w ścianie tętniaka aorty brzusznej

• Authors: Jan Skóra , Artur Pupka , Piotr Barć , Tomasz Dawiskiba

Title variants

The activity of metalloproteinases in the wall of abdominal aortic aneurysm

• Languages of publication: PL EN

Abstracts

PL

Tętniaki aorty brzusznej (AAA, abdominal aortica neurysm) stanowią jedną z głównych przyczyn wykonywania zabiegów naczyniowych. W procesie destrukcji ściany naczynia i powstania tętniaka istotną rolę spełniają metaloproteinazy. Metaloproteazy macierzy posiadają zdolność trawienia kolagenu, fi bronektyny, elastyny, lamininy. Wzrost aktywności metaloproteinaz powoduje destrukcję macierzy pozakomórkowej. W następstwie oddziaływania ciśnienia tętniczego na osłabioną ścianę aorty brzusznej dochodzi do jej dylatacji i powstania tętniaka. W wielu pracach doświadczalnych i klinicznych wykazano wzrost ekspresji genów dotyczących metaloproteinaz macierzy zewnątrzkomórkowej w ścianie tętniaków aorty brzusznej. Uzyskane wyniki służą do porównania z wynikami ekspresji genów metaloproteinaz w innych tkankach lub zdrowej aorty. Dokładne poznanie roli metaloproteinaz w patogenezie tętniaków aorty brzusznej może zostać wykorzystane w profilaktyce i leczeniu tętniaków aorty.

EN

The abdominal aortic aneurysms (AAA) constitute one of the main reasons for performing a vascular surgery. The metalloproteinases play an important role in the process of the aorta wall destruction and the aneurysm formation. The matrix metalloproteinases posses the ability to digest collagen, elastin, fibronectin and laminin. The increased activity of the matrix metalloproteinases causes the destruction of the extracellular matrix. In consequence of the blood pressure on the damaged wall of the abdominal aorta, it becomes dilated and the formation of the aneurysm occurs. In a series of experimental and clinical works an increased expression of genes for matrix metalloproteinases in the wall of abdominal aortic aneurysms has been demonstrated.. These results are used to compare with the results of metalloproteinase gene expression in other tissues or the healthy aorta. The precise knowledge of the role of MMPs in the pathogenesis of abdominal aortic aneurysms can be used in the prevention and treatment of aortic aneurysms.

Keywords

PL

tętniak; aorta; kolagen; metaloproteinazy

EN

aneurysm; aorta; collagen; metalloproteinases

• Publisher: Państwowa Medyczna Wyższa Szkoła Zawodowa w Opolu
• Journal: Puls Uczelni
• Year: 2012
• Issue: 1
• Pages: 7-10

Dates

accepted

2012-03-15

Contributors

author

Jan Skóra

• Instytut Pielęgniarstwa, Państwowa Medyczna Wyższa Szkoła Zawodowa w Opolu

author

Artur Pupka

• Katedra i Klinika Chirurgii Naczyniowej, Ogólnej i Transplantacyjnej AM Wrocław

author

Piotr Barć

• Katedra i Klinika Chirurgii Naczyniowej, Ogólnej i Transplantacyjnej AM Wrocław

author

Tomasz Dawiskiba

• Katedra i Klinika Chirurgii Naczyniowej, Ogólnej i Transplantacyjnej AM Wrocław

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Identifiers

ISSN

2080-2021