European Union and Indian Union signed the cooperation agreement in 1994 and a strategic partnership 10 years later. Europe was feeling safe and secure, which was well-described in 2003 in the European Security Strategy, so the approach to the relations with India stressed their economic aspects. In 2007, both sides have started negotiations of the Free Trade Agreement. They still have not concluded but in the meantime the world has changed dramatically. In the current international “disorder” both India and Europe are looking for new partners and vectors of influence, defending multilateralism and democratic values. The paper analyses 5 factors which severely influence these relations. They can bring both sides closer and make the strategic partnership stronger: Rise of China as a global power, Increase of American-Chinese competition and rivalry, Russia’s coming back to the international game of power, Rise of India as a regional power and global player, the world largest democracy and a counterbalance to China, Brexit and internal dynamics in the EU. The text is based, among others, on research and discussions taken under umbrella of the India–EU Think Tank Twinning Initiative – the project implemented by 10 best European and Indian think tanks.