Perspectives of population’ health status improving are in further addressing the current economic, social and environmental challenges, which take into consideration the specificity of the present civilization crisis (which is also manifested in educational space) such as disruption of the biosphere control mechanisms (which are responsible for support of the mutation pressure equilibrium on the human population quantity and gene pool), rapid development for inherently anti-biological forms of human activity, impossibility of generalized humanism postulate (the modern civilization’s basic principle), social mechanisms of internal self-destruction, emergence and starting of implementation for the qualitatively new facilities for real world fit to virtual one, preparation and emergence of new intellect forms. Observable in present time of an environmental disadaptation syndrome is caused by the negative impact of various environmental factors (air, water and food pollution, including radioactive; stress factors associated with the effects of urbanization, bad habits, financial problems, social disasters and other adverse living conditions) and primarily manifested in a negative impact on genomic unit specialized cells of the body important homeostatic systems namely the nervous, endocrine and immune. Under microenvironmental pollution of human body specialized cells the effect of traditional medicine is decreasing, therapeutic efficacy of traditional ways of prevention and treatment can be achieved during the previous application of the adaptogenic orientation individual programs – bioregulators of natural origin and endoecological rehabilitation methods (detoxification on the cell level and cell’ microenvironment). Under current crisis conditions for children, youth and adults health worsening are actual and perspective for further research of the environmental disadaptation syndrome, both for valid diagnosis and developing effective means for its prevention and treatment. The introduction of biological and socio-cultural principles of environmental education, harmonious interaction in the system people-environment restoration requires joint efforts of various specialists, because only medical-and-psychological-and-educational support can protect the future generation’s health.