The situation of Jews under the rule of Sasanians differed considerably to the situation in times of Arsacids, who looked kindly on Jewish society. The main reason for that were different aims of Persian policy, which didn’t need such a big support of local societies. In consequence, they were persecuted by the state and had to face its official religion – Mazdaism. Although our historical records are very limited in that case, in Author’s opinion, in the Sasanians Empire, circumstances could have been favourable enough for arising of the Jewish Anti-Gospel, maybe even from the Persian’s inspiration. The first moment could be dated for the reign of Shapur II, especially during the wars with Romans, the second in reign of Yezdegard I. The question however needs further research.