The aim of the article is to determine location of ethnic Ukrainians’ small industrial manufacturing in the economy of the Russian Empire of the second half of the XIX – beginning of the XX century. Primary attention is given to characterizing the causes of small industrial entrepreneurship expansion and development among ethnic Ukrainian population of Eastern Slobozhanschyna , Kuban’, Lower and Middle Volga, South-Western Siberia, the Far East and other regions of Ukrainians’ settling outside the Dnieper river territory of Ukraine and their impact on country’s economy as a whole. The main factor that stipulated for active ethnic Ukrainians’ involvement in the handicraft industry development was establishment in the administrative boundaries of many Russian provinces and regions of densely populated by the Ukrainian population territories, on which Ukrainian communities established diverse small industrial manufacturing and formed big handicraft centers. Major part of the Ukrainian diaspora in Russia was formed by migration of the Ukrainians that populated the Dnieper river territory of Ukraine to the interior provinces of the Russian Empire. Statistical data of the lists of Samara, Kuban’, Don, Stavropol, Tver’ and other regions’ populated areas, as well as that of Siberia and the Far East are presented in the article. Reproduction of small industrial entrepreneurship development in the Ukrainian ethnic areas of Russia during the second half of XIX – beginning of the XX century, its thorough scientific analysis, allows the author to refute the idea that had been rooted in the soviet historiography and stated insignificant role of the ethnic Ukrainian economy, including small industrial manufacturing, ethnic in Russian economy, their gradual decline in the market conditions with regard to the developed market economic system of the Russian Empire and extremely primitive forms, in which traditional Ukrainian crafts and handicrafts existed under the conditions, established by the Russian Empire. In the Ukrainian ethnic areas and other regions of Ukrainians’ compact and dispersed settlements in the administrative boundaries of Russian provinces and regions there were from 850 thousand to 1180 thousand of ethnic Ukrainians that were employed in the field of handicrafts and crafts while small industrial manufacturing itself gave more than 40% of all non-agricultural goods, produced in Ukrainian enclaves. In some fields this index reached up to 100%.