One of the most important decisions in every personʼs life is the one regarding vocation. The choice of oneʼs own vocation is one of the basic human and religious issues. Who has found his vocation usually enjoys a happy life. Tomáš Cardinal Špidlík, whose anniversary of birth and death we commemorate (* 17 December 1919; † 16 April 2010), dedicated a separate book to this topic. In a form of dialogue, he offers his experience in discerning one’s personal vocation and in decrypting Godʼs will. He pays special attention to the spiritual vocation and questions related to it. In the following text, we will try to reflect on selected areas regarding the issue of existence and vocation choice in the context of Špidlíkʼs experience. The topic is very current because the priestly and spiritual vocations in Slovakia have been falling fast in recent years.