The purpose of the article was to determine the functional state of the cardiorespiratory system and the vegetative regulation of the heart rhythm of male students engaged in the sports-pedagogical perfection groups on boxing when performing the dose-related physical exertion. To implement the goal, the following research methods were used: photoplethysmography, heart rate variability (HRV), cardiointervalography, spirography, tonometry, veloergometry, methods of mathematical statistics. Thus, with comparatively the same relative values of the results of the PWC170 sample, the boxer students of all weight categories, the sympathetic regulation of cardiovascular activity is dominant, which indicates the same tropic support for performing physical exertion. During the restitution period, there is a decrease in the frequency-volume parameters of the respiratory system, to a greater extent, due to the frequency of the respiratory cycles. The centralization index (according to R. M. Baievskyi) remains unrefined in comparison with the results of the sample, while maintaining a tendency to dominate the “heavyweights” of sympathicotonia balance. In this case, the ratio of low-wave to high-wave components of HRV (LF) indicates the dominance of sympathetic regulation of cardiovascular activity of boxer students of all weight categories. It is typical that students-boxers of heavy weight categories have a fairly low overall absolute level of regulatory systems activity, the LF/HF ratio is in the low-wave range, which indicates a low adaptation of the regulation of cardiac activity of boxer heavy students to submaximal load. Since the PWC170 sample is performed mainly in submaximal mode, which is characteristic for lightweight boxers and is non-specific for heavyweights, it is logical that the under-recovery of the trophic (oxygen) function in boxing students in heavy categories is due to the low functionality of the organism to the glycolytic regime of power supply.