The problem of professional sеlf-dеtеrminаtion of senior pupils occupies an important place in psychology and pedagogy. Humanization of training and education goals provides for the harmonious development of personality of the senior pupils, the manifestation of their creativity, independence, especially in choice of future profession. In psychological and pedagogical literature there are various approaches to the definition of psychological factors of making profession choice. The basic stages of formation the subject of professional sеlf-dеtеrminаtion were found out. The approaches to the stages of professional sеlf-dеtеrminаtion were selected. Profеssional sеlf-dеtеrminatiоn is viewed as a process that spans the whole period of professional activity of personality: from the emergence of professional interests, intentions,propensities to exit employment. Profеssional sеlf-dеtеrminatiоnis a complex structural formationwhich is interrelated and connected with beliefs of moral and strong-willed personality’s traits, behaviors, knowledge about the professions, practical skills are formed in accordance with the requirements of society and opportunities of the educational process at school. High school prepares senior pupils for making profession choice by methods of educational work. All training elements are important: the system of general knowledge, moral, aesthetic and physical pupil’s education. There is a system of special measures which isdesigned to prepare senior pupils for professional careers. Professional self-determination in pedagogy is understood as a process of self-knowledge and objective assessment of a person's own individual psychological characteristics, abilities, capabilities, comparing their own professionally important qualities and capabilities with the requirements that are necessary to master a particular profession, which include the choice of career, the choice of university and place of work. In author’s opinion, the senior pupil who has determined himself of what he needs and what he wants, understands and knows their capabilities, aptitudes, abilities, has a life plan; ready to operate in the system of social relations.