There are many opportunities to practise rational social and economic policy on the regional level. The function of regions within the state structure encourages social activity and improves local solutions as well as social and economical processes. Permanent economic growth is not possible without industrial prosperity. The macroeconomic changes depend on the success of individual enterprises functioning within the environment. The enterprises are the main agents increasing economic value and influencing region's economic growth. Both national and regional self-government authorities are responsible for creating proper economic environment. The effectiveness of national economic policy and success of local authorities are judged by the region's economic success. Local citizens - who also form the electorate voting in local elections - would be pleased with their self-government authorities if they experienced visible improvement of living standard. So the main goal for the self-government authorities is to maintain sustainable development and economic balance in the region. Generally speaking the regional policy is most visible if the management is rational, economic processes optimal and decision making professional. It implies the necessity of long-term strategy, precise goal-setting and precise implementation. The scale of regional policy success will depend on the region willingness to open up to the environment. It should be visible in the regional investment dynamics and in the dynamic growth in goods and services offered by the region. Without major increase in social product and exchange with their neighbours the regional problems cannot be solved.