The study of gene polymorphisms in neurotransmitter systems (HTR1A and SLC6A3) and morphofunctional characteristics in students with depression symptoms

• Authors: Negasheva Marina , Vasileva Aleksandra , Godina Elena

Title variants

PL

Badanie genowego polimorfizmu systemów neurotransmiterów (HTR1A oraz SLC6A3) oraz charakterystyka morfofunkcjonalna u studentów zobjawami depresji

• Languages of publication: EN

Abstracts

EN

In the last decades, due to the increasing level of stress, the study of different de-pressive states and search for morpho-functional and genetic markers of depression have become important for modern society. This article is an interdisciplinary study of morpho-functional characteristics and variability of genes in the neurotransmitter systems (HTR1A and SLC6A3) in young men and women with the expression of depressive symptoms. The materials used include: morpho-functional characteristics (height, weight, body circumferences, skinfold thickness in the trunk and the extremities, and characte-ristics of cardiovascular and respiratory systems); evaluation of depression symptoms performed with the Beck questionnaire; determination of polymorphisms of the HTR1A and SLC6A3 genes for 372 students from the cities of Samara and Saransk (170 men and 202 women aged 16-23, predominantly of Russian ethnicity. The results obtained are as follows: young men and women with depression symptoms are characterized by significantly different morpho-functional characteristics (p<0.05), lower adiposity and abdominal skinfold thickness, as well as a relatively higher specific metabolic rate. No differences in the frequencies of the genotypes of the neurotransmitter systems genes (DAT1, HTR1A) were found between the groups of students with or without depression symptoms. Differences in the number of individuals with the presence of depression symptoms were revealed (p<0.05) in relation to gender: these symptoms were twice as high in women (14%) as in men (7%).

PL

W ostatnich dziesięcioleciach, ze względu na rosnący poziom stresu, badania nad różnymi stanami depresyjnymi i poszukiwanie morfofunkcjonalnych i genetycznych markerów depresji stają się coraz ważniejsze dla współczesnego społeczeństwa. Celem niniejszej pracy jest interdyscyplinarne badanie cech morfofunkcjonalnych i zmienności genów w układach neuroprzekaźników (HTR1A i SLC6A3) u młodych mężczyzn i kobiet z objawami depresyjnymi. Materiał: cechy morfofunkcjonalne (wysokość i masa, obwody ciała i grubości fałdów skórnych na tułowiu i kończynach, charakterystyka układu sercowo-naczyniowego i oddechowego); ocena objawów depresji za pomocą kwestionariusza Becka; określenie polimorfizmów genów HTR1A i SLC6A3 dla 372 uczniów z miast Samara i Sarańsk (170 mężczyzn i 202 kobiety w wieku 16 do 23 lat, głównie pochodzenia rosyjskiego). Wyniki: młode kobiety i mężczyźni z obecnością stanu depresyjnego charakteryzują się zmiennie odmiennymi cechami morfofunkcjonalnymi (p< 0, 05); mniejszą otyłością i grubością fałdów skórnych brzucha, względnie wyższą specyficzną przemianą materii. Nie stwierdzono różnic w częstości genotypów genów systemów nerwowych (DAT1, HTR1A) pomiędzy grupami uczniów z objawami depresji lub bez nich. Różnice między płciami w liczbie osób z objawami depresji zostały pokazane (p< 0, 05); objawy te były dwukrotnie wyższe u kobiet (14%) niż u mężczyzn (7%).

Keywords

EN

morpho-functional characteristics; depression symptoms; genes of neurotransmitter systems

PL

charakterystyka morfofunkcjonalna; symptomy depresji; geny i systemy neurotransmiterów

• Publisher: Lubuskie Towarzystwo Naukowe
• Journal: Rocznik Lubuski
• Year: 2018
• Volume: 44
• Issue: 2a
• Pages: 43-55

Contributors

author

Negasheva Marina

• Lomonosov State University of Moscow

author

Vasileva Aleksandra

• Lomonosov State University of Moscow

author

Godina Elena

• Lomonosov State University of Moscow

References

• Angold A. (1991), The effects of age and sex on depression ratings in children and adolescents, “Journal of American Academy of Child and Adolescent Psychiatry”, Vol. 30, pp. 67-74.
• Asberg M. (1986), Biological factors in suicide: Suicide, (Ed.) Williams R., Baltimore.
• Asherson P. (2004), Attention-Deficit Hyperactivity Disorder in the postgenomic era. Eur Child & Adolescent Psychiatry, IMAGE Consortium, Vol. 13, pp. 50-70.
• Huang Y. Y., Battistuzzi C., Oquendo M. A. et al. (2004), Human 5-HT1A receptor C(1019)G polymorphism and psychopathology, Int. J. Neuropsychopharmacol, Vol. 7, pp. 441-451.
• Ilyin E. P. (2003), Differentsial’naya psykhologiya muzhchin i zhenschin (Differential Psychology of Men and Women), SPb: Piter, 393.
• Karama S., Grizenko N., Sonuga-Barke E. et al. (2008), Dopamine transporter 3’UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD, BMC Psychiatry, Vol. 17, p. 45.
• Kokorin M. V. (2005), Psykhofiziologicheskie osobennosti picnomorfnykh I astenomorfnykh zhenschin (Psychophysiological characteristics of pyknomorf and asthenic women), Nauchnyi Almanac Kafedry Antropologii, Iss. 3, pp. 249-263.
• Lemonde S., Turecki G., Bakish D. et al. (2003), Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide, The Journal of Neuroscience, no. 23(25), pp. 8788-8799.
• Levin O. S. (2006), Diagnostika i lechenie depressii pri bolezni Parkinsona (Diagnostics and treatment of depression under Parkinson disease), Nervnye bolezni, no. 2, pp. 2-8.
• Liniolla M., Virkkunen M., Scheinin M. (1983), Low cerebrospinal fluid 5-hydroxyindole acetic acid concentration differentiates impulsive from nonimpulsiv violent behavior, Life science, Vol. 33, no. 26, pp. 2609-2614.
• Pantyuk I. V., Ermalenok Yu. V. (2007), Biologicheskie I sotsial’nopsykhologicheskie osobennosti lits, stradaushchikh depressivnymi rasstroistvami (Biological and socio-psychological characteristics of people suffering from depressive states), Psychoterapiya I Klinicheskaya Psychologiya, no. 4(23), pp. 30-33.
• Persico A., Maccardi F. (1997), Genomic association between dopamine transporter gene polymorphisms and schizophrenia, Medicine genetics, Vol. 74, no. 1, pp. 53-57.
• Piccinelli M., Wilkinson G. (2000), Gender differences in depression, The British Journal of Psychiatry, Vol. 177, no. 6, pp. 486-492.
• Rowe D. C., Stever C., Gard J. M. et al. (1998), The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children, Behav Genet, Vol. 28, pp. 215-225.
• Roy A., Vikkunen M., Linnoila M. (1987), Reduced central serotonin turnover in a subgroup of alcoholics, Biological psychiatry, Vol. 11, no. 2-3, pp. 173-177.
• Sergeev V. N., Mikhailov V. I., Lebedev V. B. et al. (2013), Osnovnye mekhanismy i rol’ metabolicheskogo i kletochnogo pitaniya pri depressivnykh sostoyaniyakh (Main mekhanisms and the role of metabolic and cell nutrition in depressive states), Vestnik Nevrologii, Psykhiatrii i Neurokhirurgii, no. 5, pp. 21-35.
• Simonov P. V. (1987), Motivirovannyi mozg (Motivated Brain). M.: Nauka, 269.
• Starostina E. G. (2005), Ozhirenie kak psykhosomaticheskoe zabolevanie. (Obesity as a psychosomatic disease), Ozhirenie i Metabolism, no. 3, pp. 18-23.
• Topchyi N. V. (2005), Depressivnye rasstroistva v praktike polyklinicheskogo vracha (Depressive disorders in practice of a general practitioner), Farmateka, no. 10, pp. 2-7.
• Vandenberg D. J., Percico A. M., Hawkins A. L., et al. (1992) Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR, Genomics, Vol. 14., pp. 1104-1106.
• Vredenberg K., Krames L., Flett G. L. (1986), Sex differences in the clinical expression of depression, Sex Roles, Vol. 14, pp. 37-49.