Clinical aspects of protein glycation

• Authors: Sabina Galiniak , Izabela Krawczyk-Marć , Anna Sęk-Mastej , Natalia Leksa , Marek Biesiadecki , Stanisław Orkisz
• Languages of publication: EN

Abstracts

EN

Introduction. Glycation is a post-translational modification of proteins that depends on the non-enzymatic linkage of a ketone or aldehyde group of sugar with a free amino group of protein. Pathological effects of this process are observed in many disease states under conditions of hyperglycemia, in diabetic complications, and neurodegenerative diseases such as multiple sclerosis. Aim. In this paper we present the characteristics of the glycation process, its consequences, as well as a review of current knowledge about the role of glycation in multiple sclerosis. Material and methods. The databases EBSCO, PubMed, ScienceDirect and SpringerLink were used to search the literature. Analysis of the literature. Intermediate glycation products form a number of derivatives that contribute to oxidative stress and structural changes in the proteins, including induction of aggregation or reduction of affinity for drug proteins. Glucose products may contribute to neurodegenerative changes in patients with multiple sclerosis. Determination of protein glycation products can be successfully used to evaluate the course of multiple sclerosis as a diagnostic marker.

Keywords

EN

AGEs; glycation; advanced glycation end products; multiple sclerosis

• Publisher: Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2017
• Issue: 3
• Pages: 263-267

Contributors

author

Sabina Galiniak

• Chair of the Morphological Sciences, University of Rzeszów, Poland

author

Izabela Krawczyk-Marć

• Chair of the Morphological Sciences, University of Rzeszów, Poland

author

Anna Sęk-Mastej

• Chair of the Morphological Sciences, University of Rzeszów, Poland

author

Natalia Leksa

• Chair of the Morphological Sciences, University of Rzeszów, Poland
• Department of Neurology, MSWiA Hospital, Rzeszów, Poland

author

Marek Biesiadecki

• Chair of the Morphological Sciences, University of Rzeszów, Poland

author

Stanisław Orkisz

• Chair of the Morphological Sciences, University of Rzeszów, Poland

Identifiers

DOI

10.15584/ejcem.2017.3.10