PL EN


2017 | 2 | 110-119
Article title

Investigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopy

Content
Title variants
Languages of publication
EN
Abstracts
EN
Currently, new and easier ways of analyzing pharmaceutical drug forms and drug delivery mechanisms are being sought. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that images drug forms such as tablets, liquids and topicals and drug form behavior in living organisms on both the tissue and cellular scale. The advantages of MRI include noninvasiveness, variable sample capacity and ease of transfer of phantom results to in vitro and in vivo studies. This review concerns the usefulness of clinical MRI that cannot be understated as this technique provides non-invasive and non-destructive insight into the properties of drug delivery systems. The research discussed here concerns the use of magnetic resonance, spectroscopy and chromatography to investigate selected pharmaceuticals and covers work of selecting drugs and antibodies for modification by synthesis for evaluation by MRI. Modifications have been aimed at improving therapeutic efficacy, delivery, and MRI. Modification conditions such as (pH, concentration, temperature, and the influence of other components present in the solutions) will be discussed to understand drug delivery system improvements and the reliability and repeatability of the results obtained. We hope to explore and expand the scope of pharmaceutical imaging with MRI for application in clinical medicine.
Year
Issue
2
Pages
110-119
Physical description
Contributors
author
  • Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
  • Department of Human Immunology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
  • Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
  • Department of Human Immunology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
author
  • Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
  • Department of Electroradiology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
author
  • Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
  • Department of Experimental and Clinical Pharmacology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
  • Department of Experimental and Clinical Pharmacology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.mhp-467512ec-5e12-4ca1-ae79-3c5c1cf453ff
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