Infliximab MRI relaxation time in solution

• Authors: Zuzanna Bober , Piotr Bar , Grzegorz Pasternak , Sabina Galiniak , Dorota Bartusik-Aebisher , Rafał Filip , David Aebisher
• Languages of publication: EN

Abstracts

EN

Introduction. The use of Quantitative Magnetic Resonance Imaging to drug monitoring in vitro or in vivo can provides a powerful means to map the effects of drugs on tissue activity. Aim. The purpose of this study was to measure relaxation time of antibody phantom. For this purpose, infliximab sample was used. Material and methods. The selected methods to detect relaxation time of antibody was Magnetic Resonance Imaging technique. We detected spin-lattice (T1 ) relaxation time and discuss differences where compare to water. Results. The measurements ofspin-lattice (T1 ) relaxation time showed significant differences. The results obtained in phantom indicate that we can use this result for measurements of relaxation time in vitro. Conclusion. Infliximab is approved for severe cases of rheumatoid arthritis, together with methotrexate, for pronounced psoriasis and psoriasis-arthritis, ankylosing spondylitis as well as for chronic inflammatory bowel disease. We conclude, that Quantitative Magnetic Resonance Imaging can be used to monitor drug effects

Keywords

EN

infliximab; magnetic resonance imaging relaxation time

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2019
• Issue: 1
• Pages: 22-25

Contributors

author

Zuzanna Bober

• Department of Electroradiology,Faculty of Medicine, University of Rzeszów, Rzeszów, Poland

author

Piotr Bar

• Clinical Department of Pathomorphology, Clinical Hospital No. 2, Rzeszów, Poland

author

Grzegorz Pasternak

• Department of Gastroenterology,Faculty of Medicine, University of Rzeszów, Rzeszów, Poland

author

Sabina Galiniak

• Department of Biochemistry and General Chemistry, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland

author

Dorota Bartusik-Aebisher

• 4 Department of Biochemistry and General Chemistry, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland

author

Rafał Filip

• Department of Gastroenterology,Faculty of Medicine, University of Rzeszów, Rzeszów, Poland

author

David Aebisher

• Department of Photomedicine and Physical Chemistry, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland

Identifiers

DOI

10.15584/ejcem.2019.1.4