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Introduction. Despite advances in medical care AKI (acute kidney injury) is associated with high morbidity and mortality. The lack of adequate early renal injury biomarkers is often a problem for an early AKI diagnosis. In recent years, numerous scientific studies have been carried out which reveal new urine and serum markers to assess the period of the kidney injury before revealing its late clinical effects. In most clinical settings, AKI is due to acute renal tubular necrosis which results in protein accumulation in urine. Determination of the concentrations of proteins such as NGAL (neutrophil gelatinase-associated lipocalin) and KIM-1 (kidney injury molecule-1) are of great significance in the diagnosis of AKI. Aim. The purpose of the study was to review the literature about significance of NGAL and KIM-1 proteins for diagnosis of acute kidney injury (AKI) in clinical practice. Materials and method. Analysis of Polish and foreign literature.
Year
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Pages
28-33
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Contributors
author
- Department of Biochemistry, Institute of Clinical and Experimental Medicine, Faculty of Medicine, University of Rzeszow, Poland
author
- Department of Biochemistry, Institute of Clinical and Experimental Medicine, Faculty of Medicine, University of Rzeszow, Poland
author
- Department of Human Immunology, Faculty of Medicine, University of Rzeszow, Poland
author
- Faculty of Medicine, University of Rzeszow, Poland
- St’Queen Jadwiga Clinical District Hospital No. 2 in Rzeszow, Poland
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.mhp-7e26789f-8d88-4cff-8db3-db7e5f9d4566
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