The potential of intracellular 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine

• Authors: Natalia Leksa , Anna Pękala , Piotr Pardak , Rafał Dziedzic , Dorota Bartusik-Aebisher , Rafał Filip , Sabina Galiniak , David Aeisher
• Languages of publication: EN

Abstracts

EN

Introduction. Quantitative and accurate monitoring of tumor makes hyperpolarized carbon (13C) Magnetic Resonance Imaging and Spectroscopy (MRI/S) a powerful tool for in vivo metabolic and structural study. Moreover, the studies of the properties and functions in tumor tissue of the compounds of carbon (C) that are organic, are fundamental to tumor biochemistry. Aim. To review 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine Material and methods. An analysis of literature regarding 13C MR spectroscopy of polarized alanine. Results. Current evidence suggests that the determination of absolute configurations of amino acids play significant role in physiological mechanisms during tumor growth and treatment. Conclusions. Nearly 50% nuclear polarization for 13C can be achieved in various organic molecules when Dynamic Nuclear Polarization DNP is performed in a strong magnetic field and at cryogenic temperatures.

Keywords

EN

13C NMR; dynamic nuclear polarization hyperpolarized carbon

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2020
• Issue: 1
• Pages: 20-23

Contributors

author

Natalia Leksa

• Department of Human Anatomy, Medical College of Rzeszów University, Rzeszów, Poland

author

Anna Pękala

• Department of Gastroenterology with IBD Unit, Clinical Hospital No. 2, Rzeszów, Poland

author

Piotr Pardak

• Department of Gastroenterology with IBD Unit, Clinical Hospital No. 2, Rzeszów, Poland
• Department of Gastroenerology, Medical College of Rzeszów University, Rzeszów, Poland

author

Rafał Dziedzic

• Department of Neurosurgey, Hospital MSWiA, Rzeszow, Poland

author

Dorota Bartusik-Aebisher

• Department of Biochemistry and General Chemistry, Medical College of Rzeszów University, Rzeszów, Poland

author

Rafał Filip

• Department of Gastroenterology with IBD Unit, Clinical Hospital No. 2, Rzeszów, Poland
• Department of Gastroenerology, Medical College of Rzeszów University, Rzeszów, Poland

author

Sabina Galiniak

• Department of Biochemistry and General Chemistry, Medical College of Rzeszów University, Rzeszów, Poland

author

David Aeisher

• Department of Photomedicine and Physical Chemistry, Medical College of Rzeszów University, Rzeszów, Poland

Identifiers

DOI

10.15584/ejcem.2020.1.4