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2020 | 1 | 20-23
Article title

The potential of intracellular 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine

Content
Title variants
Languages of publication
EN
Abstracts
EN
Introduction. Quantitative and accurate monitoring of tumor makes hyperpolarized carbon (13C) Magnetic Resonance Imaging and Spectroscopy (MRI/S) a powerful tool for in vivo metabolic and structural study. Moreover, the studies of the properties and functions in tumor tissue of the compounds of carbon (C) that are organic, are fundamental to tumor biochemistry. Aim. To review 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine Material and methods. An analysis of literature regarding 13C MR spectroscopy of polarized alanine. Results. Current evidence suggests that the determination of absolute configurations of amino acids play significant role in physiological mechanisms during tumor growth and treatment. Conclusions. Nearly 50% nuclear polarization for 13C can be achieved in various organic molecules when Dynamic Nuclear Polarization DNP is performed in a strong magnetic field and at cryogenic temperatures.
Year
Issue
1
Pages
20-23
Physical description
Contributors
author
  • Department of Human Anatomy, Medical College of Rzeszów University, Rzeszów, Poland
author
  • Department of Gastroenterology with IBD Unit, Clinical Hospital No. 2, Rzeszów, Poland
author
  • Department of Gastroenterology with IBD Unit, Clinical Hospital No. 2, Rzeszów, Poland
  • Department of Gastroenerology, Medical College of Rzeszów University, Rzeszów, Poland
  • Department of Neurosurgey, Hospital MSWiA, Rzeszow, Poland
  • Department of Biochemistry and General Chemistry, Medical College of Rzeszów University, Rzeszów, Poland
author
  • Department of Gastroenterology with IBD Unit, Clinical Hospital No. 2, Rzeszów, Poland
  • Department of Gastroenerology, Medical College of Rzeszów University, Rzeszów, Poland
  • Department of Biochemistry and General Chemistry, Medical College of Rzeszów University, Rzeszów, Poland
author
  • Department of Photomedicine and Physical Chemistry, Medical College of Rzeszów University, Rzeszów, Poland
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.mhp-adaa2c78-78b6-4482-b8b9-c09352144207
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