PL EN


2017 | 2 | 141-144
Article title

An overview of the preclinical and clinical studies of the effects of tumor treating fields on malignant glioma cells

Content
Title variants
Languages of publication
EN
Abstracts
EN
Anaplastic astrocytoma (AA, WHO grade III) and glioblastoma multiforme (GBM, WHO grade IV) are malignant tumors of the brain. The average survival time of patients with GMB is approximately one year and two years in the case of anaplastic astrocytoma with standard therapy based on surgical tumor resection followed by chemotherapy or radiotherapy. High invasiveness of gliomas, the ability of rapid division and so-called diffusive infiltration of tumor cells into normal brain tissue, which prevents complete surgical removal, are hallmarks of theses tumors. Therefore, new specific therapies for eliminating cancer cells are needed to treat this tumors. Recently, it has been demonstrated that alternating electric field, also known as tumor treating fields (TTFields) has a unique mechanism of destroying glioma cells. TTFields applies electromagnetic energy frequency-dependent and intensitydependent and disrupts cancer cell replication as they undergo mitosis. Futhermore, TTFields turn out to act comparably to conventional chemotherapeutics, lacking numerous side adverse associated with chemotherapy. The authors provide an up-todate review of the mechanism of action as well as preclinical and clinical data on TTFields.
Year
Issue
2
Pages
141-144
Physical description
Contributors
  • Department of Medical Biology, Institute of Experimental and Clinical Medicine, Medical Faculty of University of Rzeszow, Poland
  • Department of Medical Biology, Institute of Experimental and Clinical Medicine, Medical Faculty of University of Rzeszow, Poland
  • Centre for Innovative Research in Medical and Natural Sciences, Medical Faculty of University of Rzeszow, Poland
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.mhp-c474584b-2dec-41af-ae90-10b91908226e
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.