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Prevention and Struggle Against Epidemics on the South-Eastern Borderlands of the Commonwealth in the Times of Stanisław August Poniatowski Epidemics posed serious threat in the 18th century Polish-Lithuanian Commonwealth. Their most common appearance was evidenced in the south-eastern borderlands, and they often spread towards the center of the state with the movement of merchants and the military. In order to prevent the spread of these, a special quarantine houses were established on the borders. It were mainly the borderland magnates, as well as the state territorial administration headed by the Committee of Royal Treasury, that took a lead in work towards prevention of the epidemics. In the times of Stanisław August Poniatowski the most important quarantine houses functioned in Mohylew, Bałta, Białogród, Żwaniec and Jampol.