Influence of electromagnetic field (1800 MHz) on lipid peroxidation in brain, blood, liver and kidney in rats

• Authors: Paweł Bodera , Wanda Stankiewicz , Bożena Antkowiak , Małgorzata Paluch , Jarosław Kieliszek , Jaromir Sobiech , Marcin Niemcewicz

Abstracts

EN

Objectives The aim of this study is the evaluation of the influence of repeated (5 times for 15 min) exposure to electromagnetic field (EMF) of 1800 MHz frequency on tissue lipid peroxidation (LPO) both in normal and inflammatory state, combined with analgesic treatment. Material and Methods The concentration of malondialdehyde (MDA) as the end-product of the lipid peroxidation (LPO) was estimated in blood, liver, kidneys, and brain of Wistar rats, both healthy and those with complete Freund’s adjuvant (CFA)-induced persistent paw inflammation. Results The slightly elevated levels of the MDA in blood, kidney, and brain were observed among healthy rats in electromagnetic field (EMF)-exposed groups, treated with tramadol (TRAM/EMF and exposed to the EMF). The malondialdehyde remained at the same level in the liver in all investigated groups: the control group (CON), the exposed group (EMF), treated with tramadol (TRAM) as well as exposed to and treated with tramadol (TRAM/EMF). In the group of animals treated with the complete Freund’s adjuvant (CFA) we also observed slightly increased values of the MDA in the case of the control group (CON) and the exposed groups (EMF and TRAM/EMF). The MDA values concerning kidneys remained at the same levels in the control, exposed, and not-exposed group treated with tramadol. Results for healthy rats and animals with inflammation did not differ significantly. Conclusions The electromagnetic field exposure (EMF), applied in the repeated manner together with opioid drug tramadol (TRAM), slightly enhanced lipid peroxidation level in brain, blood, and kidneys.

Keywords

EN

electromagnetic field; lipid peroxidation; malondialdehyde; rats; analgesics; tramadol

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2015
• Volume: 28
• Issue: 4
• Pages: 751-759

Dates

published

2015

Contributors

author

Paweł Bodera

• Military Institute of Hygiene and Epidemiology, Warszawa, Poland (Department of Microwave Safety)

author

Wanda Stankiewicz

• Military Institute of Hygiene and Epidemiology, Warszawa, Poland (Department of Microwave Safety)

author

Bożena Antkowiak

• Military Institute of Hygiene and Epidemiology, Warszawa, Poland (Department of Pharmacology and Toxicology)

author

Małgorzata Paluch

• Military Institute of Hygiene and Epidemiology, Warszawa, Poland (Department of Pharmacology and Toxicology)

author

Jarosław Kieliszek

• Military Institute of Hygiene and Epidemiology, Warszawa, Poland (Department of Microwave Safety)

author

Jaromir Sobiech

• Military Institute of Hygiene and Epidemiology, Warszawa, Poland (Department of Microwave Safety)

author

Marcin Niemcewicz

• Military Institute of Hygiene and Epidemiology, Puławy, Poland (Biological Threat Identification and Countermeasure Center)

Identifiers

DOI

10.13075/ijomeh.1896.00255

Biblioteka Nauki

2177234