Exhaled breath malondialdehyde, spirometric results and dust exposure assessment in ceramics production workers

• Authors: Mohammad J. Sakhvidi , Javad Biabani Ardekani , Ali Firoozichahak , Javad Zavarreza , Mohammad Hajaghazade , Mehrdad Mostaghaci , Amirhooshang Mehrparvar , Abolfazl Barkhordari

Abstracts

EN

Introduction The study aimed at measuring exhaled breath malondialdehyde (EBC-MDA) in workers exposed to dust containing silica and at its comparison with the non-exposed control group. Material and methods The cross sectional, case-control study (N = 50) was performed in a tile and ceramics production factory in Yazd, Iran. EBC-MDA was quantified in exhaled breath of the participants by a lab made breath sampler. Exposure intensity was measured according to the NIOSH 0600 method in selected homogeneous exposure groups. Additionally, spirometry test was conducted to investigate a correlation between EBC-MDA and spirometric findings in the exposed workers. Results There was no difference in the observed exposure intensities of silica containing dust in different units. However, “coating preparation” was the unit with the highest concentration of dust. Although, the level of EBC-MDA in the cases was slightly higher than in the controls, the difference was not statistically significant (U = 252, p = 0.464). A significant and positive correlation was found between dust exposure intensity in working units and the measured EBC-MDA of workers (r = 0.467, N = 25, p = 0.027). There were also no statistically significant differences among job categories in the exposed group for the values of FEV1% (F(3, 44) = 0.656, p = 0.584), FVC% (F(3, 44) = 1.417, p = 0.172), and FEV1/FVC% (F(3, 44) = 1.929, p = 0.139). Conclusions The results showed a significant correlation between respirable dust exposure intensity and the level of EBC-MDA of the exposed subjects. However, our results did not show a significant correlation between lung function decreases and EBC-MDA.

Keywords

EN

Oxidative stress; occupational exposures; spirometry; breath condensate; malondialdehyde

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2015
• Volume: 28
• Issue: 1
• Pages: 81-89

Dates

published

2015

Contributors

author

Mohammad J. Sakhvidi

• Shahid Sadoughi University of Medical Sciences, Yazd, Iran (Faculty of Health, Department of Occupational Health)

author

Javad Biabani Ardekani

• Shahid Sadoughi University of Medical Sciences, Yazd, Iran (Food and Drug Laboratory)

author

Ali Firoozichahak

• Bam University of Medical Sciences, Kerman, Iran (Faculty of Health, Department of Occupational Health)

author

Javad Zavarreza

• Shahid Sadoughi University of Medical Sciences, Yazd, Iran (Faculty of Medicine, Department of Clinical Biochemistry)

author

Mohammad Hajaghazade

• Urmia University of Medical Sciences, Urmia, Iran (Health Faculty, Department of Occupational Health)

author

Mehrdad Mostaghaci

• Shahid Sadoughi University of Medical Sciences, Yazd, Iran (Faculty of Medicine, Department of Occupational Medicine)

author

Amirhooshang Mehrparvar

• Shahid Sadoughi University of Medical Sciences, Yazd, Iran (Faculty of Medicine, Department of Occupational Medicine)

author

Abolfazl Barkhordari

• Shahid Sadoughi University of Medical Sciences, Yazd, Iran (Faculty of Health, Department of Occupational Health)

Identifiers

DOI

10.13075/ijomeh.1896.00262

Biblioteka Nauki

2177001