Molecular profile of sensitization in subjects with short occupational exposure to latex

• Authors: Monica Lamberti , Rosaria Buonanno , Chiara Ritonnaro , Giancarlo Giovane , Vincenzo Crispino , Antonia Feola , Nicola Medici , Nicola Sannolo , Angelina Di Carlo , Marina Di Domenico

Abstracts

EN

Objectives We examined the prevalence of latex allergy in subjects with occupational exposure to latex allergens for less than 5 years, determining the disease spectrum in symptomatic workers. We identified the most frequent molecular allergens by Immuno- CAP (ICAP), correlating the findings with skin prick test (SPT) results. Material and Methods Seven hundred twenty-three healthcare students using latex gloves on a regular basis were invited to participate in a baseline questionnaire screening. An ICAP serum test was performed only when a possible latex allergy was indicated by the questionnaire. Results The total number of participants responding to the baseline survey was 619. Glove-related symptoms were indicated by 4% (N = 25) of the students. The most common symptom was contact dermatitis (N = 18, 72%). In 12 subjects, ICAP revealed a real sensitization to latex, with a recombinant latex allergen profile showing a high frequency for rHev b 6.01 specific immunoglobulin E (sIgE) (N = 9, 67%). In these individuals, skin symptoms were more prevalent than other types (88%). Conclusions The combined positivity for rHev b 6.01, rHev 8 and rHev b 5 determined by ICAP identified 92% of latex-allergic subjects with short-term exposure to latex.

Keywords

EN

occupational exposure; ImmunoCAP; natural rubber latex; skin prick test; contact dermatitis; gloves

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2015
• Volume: 28
• Issue: 5
• Pages: 841-848

Dates

published

2015

Contributors

author

Monica Lamberti

• Second University of Naples, Naples, Italy (Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine)

author

Rosaria Buonanno

• Second University of Naples, Naples, Italy (Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine)

author

Chiara Ritonnaro

• Second University of Naples, Naples, Italy (Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine)

author

Giancarlo Giovane

• Second University of Naples, Naples, Italy (Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine)

author

Vincenzo Crispino

• Second University of Naples, Naples, Italy (Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine)

author

Antonia Feola

• Second University of Naples, Naples, Italy (Department of Biochemistry, Biophysics and General Pathology)

author

Nicola Medici

• Second University of Naples, Naples, Italy (Department of Biochemistry, Biophysics and General Pathology)

author

Nicola Sannolo

• Second University of Naples, Naples, Italy (Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine)

author

Angelina Di Carlo

• Sapienza University of Rome, Rome, Italy (Department of Medico-Surgical Sciences and Biotechnologies)

author

Marina Di Domenico

• Second University of Naples, Naples, Italy (Department of Biochemistry, Biophysics and General Pathology)

Identifiers

DOI

10.13075/ijomeh.1896.00413

Biblioteka Nauki

2177165