Quantitation of anticancer drugs – Cyclophosphamide and ifosfamide in urine and water sewage samples by gas chromatography–mass spectrometry

• Authors: Veeravan Lekskulchai

Abstracts

EN

Objectives Cyclophosphamide (CP) and ifosfamide (IF) are effective anti-cancer drugs but their genotoxicity can harm everyone contacting them occupationally or environmentally. Therefore, a sensitive method for monitoring their amounts in biological and environmental samples is needed. This has aimed to develop a method for analyzing these drugs in urine and water sewage samples. Material and Methods The drug spiked samples were extracted, derivatized, and analyzed by gas chromatography–mass spectrometry and the analytical parameters were validated. Results The method gave linear calibration curves at the concentrations of 0–190 nmol/l. It had the quantitation limit of 3.8 nmol/l and showed acceptable specificity, accuracy, recovery and precision. Conclusions The developed method can be used reliably for monitoring CP and IF concentrations in urine and water sewage. The method will be applied for preventing health risk from occupational and environmental exposures to these drugs. Int J Occup Med Environ Health 2016;29(5):815–822

Keywords

EN

environment; cyclophosphamide; antineoplastic agents; gas chromatography–mass spectrometry; ifosfamide; sensitive and specificity

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2016
• Volume: 29
• Issue: 5
• Pages: 815-822

Dates

published

2016

Contributors

author

Veeravan Lekskulchai

• Srinakharinwirot University, Bangkok, Thailand (Faculty of Medicine, Department of Pathology)

Identifiers

DOI

10.13075/ijomeh.1896.00773

Biblioteka Nauki

2168354