The effect of hymenoptera venom immunotherapy on neutrophils, interleukin 8 (IL-8) and interleukin 17 (IL-17)

• Authors: Krzysztof Pałgan , Magdalena Żbikowska-Gotz , Robert Zacniewski , Zbigniew Bartuzi

Abstracts

EN

ObjectivesVenom immunotherapy (VIT) is an effective treatment method and is addressed to patients with a history of an anaphylactic reaction to Hymenoptera stings. However, the immunological mechanisms of protection have not been explained yet. The objective of this study was to analyze neutrophils, interleukin 8 (IL-8) and interleukin 17 (IL-17) before and after the initial phase of the immunotherapy.Material and MethodsOverall, 40 individuals, including 20 wasp venom sensitized and 20 bee venom sensitized patients, were included in the study. The patients had had a history of severe allergic reactions type III and IV according to Mueller’s classification. An ultra-rush VIT protocol was used in this study. The concentration of serum IL-8 and IL-17A was determined using the ELISA enzymatic method.ResultsThe authors demonstrated a significant rise in the IL-8 level after the immunotherapy, compared to baseline (14.9 vs. 24.7, p < 0.05). The rise in the neutrophils level was also noticeable but proved to be barely out of the range of statistical significance (4.3 vs. 5.0, p = 0.06). The shift in IL-17A was negligent and not statistically significant in the paired samples t-test (1.6 vs. 1.5, p = 0.34)ConclusionsVenom immunotherapy induces neutrophils and IL-8 activity after 2 days. After the desensitization, the level of IL-17A did not change.

Keywords

EN

bee; IL-8; IL-17A; venom immunotherapy; wasp; neutrophils

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2020
• Volume: 33
• Issue: 6
• Pages: 811-817

Dates

published

2020

Contributors

author

Krzysztof Pałgan

• Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland (Department of Allergology, Clinical Immunology and Internal Diseases)

author

Magdalena Żbikowska-Gotz

• Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland (Department of Allergology, Clinical Immunology and Internal Diseases)

author

Robert Zacniewski

• Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland (Department of Allergology, Clinical Immunology and Internal Diseases)

author

Zbigniew Bartuzi

• Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland (Department of Allergology, Clinical Immunology and Internal Diseases)

Identifiers

DOI

10.13075/ijomeh.1896.01435

Biblioteka Nauki

2116499